When taking cyclophosphamide, what fluid intake is the client advised to maintain?

When taking cyclophosphamide, clients are advised to maintain a fluid intake of 2000 to 3000 mL per day. This recommendation is crucial for several reasons. Cyclophosphamide can be metabolized to compounds that can irritate the bladder, leading to a condition known as hemorrhagic cystitis. By increasing fluid intake, the concentration of these irritating metabolites in the bladder is diluted, reducing the risk of bladder-related complications. Additionally, increased hydration helps to ensure adequate kidney function and promotes the excretion of the drug and its metabolites, minimizing potential toxicity. Thus, adhering to this fluid intake range is essential for ensuring the safety and effectiveness of treatment while safeguarding the patient's urinary tract health.